Psoriasis: familial predisposition and environmental factors.

Familial predisposition and genetic risk factors for lymphoma.

Our understanding of familial predisposition to lymphoma (collectively defined as non-Hodgkin lymphoma [NHL], Hodgkin lymphoma [HL], and chronic lymphocytic leukemia [CLL]) outside of rare hereditary syndromes has progressed rapidly during the last decade. First-degree relatives of NHL, HL, and CLL patients have an ∼1.7-fold, 3.1-fold, and 8.5-fold elevated risk of developing NHL, HL, and CLL, ...

Mitochondria and Familial Predisposition to Breast Cancer

Mitochondrial genome and functional alterations are related to various diseases including cancer. In all cases, the role of these organelles is associated with defects in oxidative energy metabolism and control of tumor-induced oxidative stress. The present study examines the involvement of mitochondrial DNA in cancer and in particular in breast cancer. Furthermore, since mitochondrial DNA is m...

Familial congenital heart disease. I. Genetic and environmental factors.

W HILE REMARKABLE advances have been made during the past two decades in the diagnosis and medical and surgical management of congenital heart disease, little progress has been made in understanding etiology. With the hope that new information might be gained about environmental factors, genetic constitution, and their interplay, we have directed our attention to a group of families in which th...

Familial Congenital Heart Disease I. Genetic and Environmental Factors

W HILE REMARKABLE advances have been made during the past two decades in the diagnosis and medical and surgical management of congenital heart disease, little progress has been made in understanding etiology. With the hope that new information might be gained about environmental factors, genetic constitution, and their interplay, we have directed our attention to a group of families in which th...

Genetic Basis of Familial Lymphoma Predisposition